Hair and fingernail gadolinium ICP-MS contents in an overdose case associated with nephrogenic systemic fibrosis.
Identifieur interne : 000A28 ( France/Analysis ); précédent : 000A27; suivant : 000A29Hair and fingernail gadolinium ICP-MS contents in an overdose case associated with nephrogenic systemic fibrosis.
Auteurs : E. Saussereau [France] ; C. Lacroix ; A. Cattaneo ; L. Mahieu ; J P GoulleSource :
- Forensic science international [ 1872-6283 ] ; 2008.
English descriptors
- KwdEn :
- Contrast Media (adverse effects), Contrast Media (analysis), Drug Overdose, Female, Fibrosis, Gadolinium DTPA (adverse effects), Gadolinium DTPA (analysis), Hair (chemistry), Half-Life, Humans, Kidney Failure, Chronic (complications), Magnetic Resonance Imaging, Meglumine (adverse effects), Meglumine (analysis), Middle Aged, Nails (chemistry), Organometallic Compounds (adverse effects), Organometallic Compounds (analysis), Skin (pathology), Skin Diseases (chemically induced), Spectrophotometry, Atomic.
- MESH :
- chemical , adverse effects : Contrast Media, Gadolinium DTPA, Meglumine, Organometallic Compounds.
- chemical , analysis : Contrast Media, Gadolinium DTPA, Meglumine, Organometallic Compounds.
- chemically induced : Skin Diseases.
- chemistry : Hair, Nails.
- complications : Kidney Failure, Chronic.
- pathology : Skin.
- Drug Overdose, Female, Fibrosis, Half-Life, Humans, Magnetic Resonance Imaging, Middle Aged, Spectrophotometry, Atomic.
Abstract
Nephrogenic systemic fibrosis (NSF) is a rare acquired disorder affecting renal insufficiency patients. There is a growing recognition of the association between the rapid rise in the use of gadolinium (Gd)-containing contrast agents for magnetic resonance imaging (MRI), and the occurrence of acute nephrogenic systemic fibrosis. This case report concerns a 62-year-old woman with chronic renal insufficiency who underwent numerous MRI examinations using Gd-based contrast agents. For the first time, to our knowledge, Gd was performed in the NSF patient's blood, as well as in hair and in fingernails by inductively plasma coupled mass spectrometry. Gd contents in blood, hair and in fingernails were initially 300 to 1000 times higher compared to controls. These results are a new illustration of the strong association between the frequent use of Gd-based contrast media and NSF in patients with kidney diseases. Gd quantitative determination could be of major interest for patients with renal failure who are required to undergo repeated gadolinium-enhanced MRI examinations.
DOI: 10.1016/j.forsciint.2007.06.026
PubMed: 17983714
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000258
- to stream PubMed, to step Curation: 000258
- to stream PubMed, to step Checkpoint: 000258
- to stream Ncbi, to step Merge: 000198
- to stream Ncbi, to step Curation: 000198
- to stream Ncbi, to step Checkpoint: 000198
- to stream Main, to step Merge: 000D63
- to stream Main, to step Curation: 000D52
- to stream Main, to step Exploration: 000D52
- to stream France, to step Extraction: 000A28
Links to Exploration step
pubmed:17983714Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hair and fingernail gadolinium ICP-MS contents in an overdose case associated with nephrogenic systemic fibrosis.</title><author><name sortKey="Saussereau, E" sort="Saussereau, E" uniqKey="Saussereau E" first="E" last="Saussereau">E. Saussereau</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacokinetic and Toxicology Laboratory, J. Monod Hospital, F-76083 Le Havre Cedex, France. esaussereau@ch-havre.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacokinetic and Toxicology Laboratory, J. Monod Hospital, F-76083 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name></author><author><name sortKey="Cattaneo, A" sort="Cattaneo, A" uniqKey="Cattaneo A" first="A" last="Cattaneo">A. Cattaneo</name></author><author><name sortKey="Mahieu, L" sort="Mahieu, L" uniqKey="Mahieu L" first="L" last="Mahieu">L. Mahieu</name></author><author><name sortKey="Goulle, J P" sort="Goulle, J P" uniqKey="Goulle J" first="J P" last="Goulle">J P Goulle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:17983714</idno><idno type="pmid">17983714</idno><idno type="doi">10.1016/j.forsciint.2007.06.026</idno><idno type="wicri:Area/PubMed/Corpus">000258</idno><idno type="wicri:Area/PubMed/Curation">000258</idno><idno type="wicri:Area/PubMed/Checkpoint">000258</idno><idno type="wicri:Area/Ncbi/Merge">000198</idno><idno type="wicri:Area/Ncbi/Curation">000198</idno><idno type="wicri:Area/Ncbi/Checkpoint">000198</idno><idno type="wicri:Area/Main/Merge">000D63</idno><idno type="wicri:Area/Main/Curation">000D52</idno><idno type="wicri:Area/Main/Exploration">000D52</idno><idno type="wicri:Area/France/Extraction">000A28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hair and fingernail gadolinium ICP-MS contents in an overdose case associated with nephrogenic systemic fibrosis.</title><author><name sortKey="Saussereau, E" sort="Saussereau, E" uniqKey="Saussereau E" first="E" last="Saussereau">E. Saussereau</name><affiliation wicri:level="3"><nlm:affiliation>Pharmacokinetic and Toxicology Laboratory, J. Monod Hospital, F-76083 Le Havre Cedex, France. esaussereau@ch-havre.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacokinetic and Toxicology Laboratory, J. Monod Hospital, F-76083 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name></author><author><name sortKey="Cattaneo, A" sort="Cattaneo, A" uniqKey="Cattaneo A" first="A" last="Cattaneo">A. Cattaneo</name></author><author><name sortKey="Mahieu, L" sort="Mahieu, L" uniqKey="Mahieu L" first="L" last="Mahieu">L. Mahieu</name></author><author><name sortKey="Goulle, J P" sort="Goulle, J P" uniqKey="Goulle J" first="J P" last="Goulle">J P Goulle</name></author></analytic><series><title level="j">Forensic science international</title><idno type="eISSN">1872-6283</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Contrast Media (adverse effects)</term><term>Contrast Media (analysis)</term><term>Drug Overdose</term><term>Female</term><term>Fibrosis</term><term>Gadolinium DTPA (adverse effects)</term><term>Gadolinium DTPA (analysis)</term><term>Hair (chemistry)</term><term>Half-Life</term><term>Humans</term><term>Kidney Failure, Chronic (complications)</term><term>Magnetic Resonance Imaging</term><term>Meglumine (adverse effects)</term><term>Meglumine (analysis)</term><term>Middle Aged</term><term>Nails (chemistry)</term><term>Organometallic Compounds (adverse effects)</term><term>Organometallic Compounds (analysis)</term><term>Skin (pathology)</term><term>Skin Diseases (chemically induced)</term><term>Spectrophotometry, Atomic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Contrast Media</term><term>Gadolinium DTPA</term><term>Meglumine</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Contrast Media</term><term>Gadolinium DTPA</term><term>Meglumine</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Skin Diseases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hair</term><term>Nails</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Kidney Failure, Chronic</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Overdose</term><term>Female</term><term>Fibrosis</term><term>Half-Life</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Middle Aged</term><term>Spectrophotometry, Atomic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nephrogenic systemic fibrosis (NSF) is a rare acquired disorder affecting renal insufficiency patients. There is a growing recognition of the association between the rapid rise in the use of gadolinium (Gd)-containing contrast agents for magnetic resonance imaging (MRI), and the occurrence of acute nephrogenic systemic fibrosis. This case report concerns a 62-year-old woman with chronic renal insufficiency who underwent numerous MRI examinations using Gd-based contrast agents. For the first time, to our knowledge, Gd was performed in the NSF patient's blood, as well as in hair and in fingernails by inductively plasma coupled mass spectrometry. Gd contents in blood, hair and in fingernails were initially 300 to 1000 times higher compared to controls. These results are a new illustration of the strong association between the frequent use of Gd-based contrast media and NSF in patients with kidney diseases. Gd quantitative determination could be of major interest for patients with renal failure who are required to undergo repeated gadolinium-enhanced MRI examinations.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><noCountry><name sortKey="Cattaneo, A" sort="Cattaneo, A" uniqKey="Cattaneo A" first="A" last="Cattaneo">A. Cattaneo</name><name sortKey="Goulle, J P" sort="Goulle, J P" uniqKey="Goulle J" first="J P" last="Goulle">J P Goulle</name><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name><name sortKey="Mahieu, L" sort="Mahieu, L" uniqKey="Mahieu L" first="L" last="Mahieu">L. Mahieu</name></noCountry><country name="France"><region name="Région Normandie"><name sortKey="Saussereau, E" sort="Saussereau, E" uniqKey="Saussereau E" first="E" last="Saussereau">E. Saussereau</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A28 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000A28 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= France
|étape= Analysis
|type= RBID
|clé= pubmed:17983714
|texte= Hair and fingernail gadolinium ICP-MS contents in an overdose case associated with nephrogenic systemic fibrosis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:17983714" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |